Structure of theDietziaMrp complex reveals molecular mechanism of this giant bacterial sodium proton pump
نویسندگان
چکیده
منابع مشابه
A long road towards the structure of respiratory complex I, a giant molecular proton pump.
Complex I (NADH:ubiquinone oxidoreductase) is central to cellular energy production, being the first and largest enzyme of the respiratory chain in mitochondria. It couples electron transfer from NADH to ubiquinone with proton translocation across the inner mitochondrial membrane and is involved in a wide range of human neurodegenerative disorders. Mammalian complex I is composed of 44 differen...
متن کاملOn the molecular mechanism of the proton pump in photosynthesis.
Basierend auf der Detailstruktur der Thylakoidmembran wird ein allgemein gültiger molekularer Mechanismus für den Protonentransport über biologische Membranen vorgeschlagen. Es wird an genommen, daß aufgrund einer Redoxreaktion auf der Membranaußenseite eine Umpolarisierung innerhalb der Phospholipidschicht induziert wird, die zu einer Protonentranslokation führt. In diesem Pumpmodell wird die...
متن کاملThe dichotomy of complex I: a sodium ion pump or a proton pump.
C omplex I (NADH quinone oxidoreductase) is the only enzyme of the membrane-bound respiratory chain to remain a ‘‘black box.’’ Atomic resolution structural models are available for three of the four energy-transducing respiratory complexes: the cytochrome bc1 complex, cytochrome oxidase, and the F1 domain of ATP synthase. Detailed mechanisms that integrate these structural models with the resul...
متن کاملEstablishing the Molecular Mechanism of Sodium/ Proton Exchangers
Sodium/proton exchangers are ubiquitous secondary active transporters that can be found in all kingdoms of life. These proteins facilitate the transport of protons in exchange for sodium ions to help regulate internal pH, sodium levels, and cell volume. Na+/H+ exchangers belong to the SLC9 family and are involved in many physiological processes including cell proliferation, cell migration and v...
متن کاملStructure and transport mechanism of the sodium/proton antiporter MjNhaP1
Sodium/proton antiporters are essential for sodium and pH homeostasis and play a major role in human health and disease. We determined the structures of the archaeal sodium/proton antiporter MjNhaP1 in two complementary states. The inward-open state was obtained by x-ray crystallography in the presence of sodium at pH 8, where the transporter is highly active. The outward-open state was obtaine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2006276117